Detailed view for Bm1_44580

Basic information

TDR Targets ID: 243754
Brugia malayi, sterile alpha and TIR motif containing protein 1 isoform a
Source Database / ID:  GenBank

pI: 6.6741 | Length (AA): 951 | MW (Da): 107105 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00536   SAM domain (Sterile alpha motif)
PF07647   SAM domain (Sterile alpha motif)
PF13676   TIR domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0031224   intrinsic to membrane  
GO:0005488   binding  
GO:0004888   transmembrane receptor activity  
GO:0005515   protein binding  
GO:0045087   innate immune response  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 268 4k6j (A) 872 1183 10.00 0 0.07 0.342381 -0.14
79 789 1z3h (A) 42 801 12.00 0 1 0.767134 0.77
205 944 1qgr (A) 4 747 10.00 0 0.81 0.789628 0.68
580 644 2f3n (A) 2 65 27.00 0 1 0.543849 -1.47
583 647 4pzo (A) 919 983 34.00 0.32 1 0.529749 -0.68
584 644 2qkq (A) 908 968 16.00 0 0.69 0.339643 -1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134766)

Species Accession Gene Product
Brugia malayi Bm1_44580   sterile alpha and TIR motif containing protein 1 isoform a
Caenorhabditis elegans CELE_F13B10.1   Protein TIR-1, isoform A
Drosophila melanogaster Dmel_CG43119   Ectoderm-expressed 4
Echinococcus granulosus EgrG_001091600   sterile alpha and tir motif containing protein
Echinococcus multilocularis EmuJ_001091600   sterile alpha and tir motif containing protein
Homo sapiens 23098   sterile alpha and TIR motif containing 1
Loa Loa (eye worm) LOAG_11466   hypothetical protein
Loa Loa (eye worm) LOAG_08461   toll and interleukin 1 receptor domain-containing protein isoform f
Loa Loa (eye worm) LOAG_15862   hypothetical protein
Mus musculus ENSMUSG00000050132   sterile alpha and HEAT/Armadillo motif containing 1
Schistosoma japonicum Sjp_0057800   Sterile alpha and TIR motif-containing protein 1, putative
Schistosoma mansoni Smp_012780   sarm1
Schmidtea mediterranea mk4.008544.03   Ectoderm-expressed 4
Schmidtea mediterranea mk4.010559.00   Ectoderm-expressed 4
Schmidtea mediterranea mk4.003912.00   Ectoderm-expressed 4
Schmidtea mediterranea mk4.010559.01   Ectoderm-expressed 4

Essentiality

Bm1_44580 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F13B10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F13B10.1 Caenorhabditis elegans larval arrest wormbase
CELE_F13B10.1 Caenorhabditis elegans larval lethal wormbase
CELE_F13B10.1 Caenorhabditis elegans slow growth wormbase
CELE_F13B10.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_44580 (Brugia malayi), sterile alpha and TIR motif containing protein 1 isoform a
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